Figure 8.

A diagram illustrating the mechanisms of action of CXCL4 in regulating LV remodelling following MI. MI triggers macrophage infiltration into the infarct area, which releases abundant CXCL4. CXCL4 decreases CD36 expression in MMP-9 independent (direct) and dependent (cleavage of CD36) modes to inhibit macrophage phagocytosis of dead myocytes and neutrophils, which results in impaired removal of debris and adverse remodelling post-MI. In addition, CXCL4 up-regulates Ccr4 and Itgb4 and down-regulates Adamts8, which may result in LV dilation. The cell images are from Servier Medical Art (www.servier.com).