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. 2019 Jan 8;2019:7452019. doi: 10.1155/2019/7452019

Table 6.

Whole blood gene expression in kidney transplant recipients (data presented as ΔΔCT).

Gene Control group mean ± SD (median; IQR) Time from KTx Mean ± SD (median; IQR) p-KTx vs. control
CD4 0.00 ± 1.01 (0.44; -0.52–0.65) 1 week 1.27 ± 1.71 (1.04; 0.58–1.62) 0.003
1 month 0.95 ± 0.98 (0.76; 0.50–0.99) 0.010
3 months 1.26 ± 0.94 (1.02; 0.79–1.74) <0.001
6 months 1.28 ± 1.42 (1.10; 0.53–1.68) 0.001
12 months 0.64 ± 1.24 (0.76; 0.33–1.10) 0.028
7.9 ± 2.2 y. 0.31 ± 1.25 (0.56; -0.08–1.14) 0.171
CD8 0.00 ± 1.43 (0.02; -0.56–1.06) 1 week 0.47 ± 2.15 (-0.09; -0.89–1.26) 0.949
1 month 0.95 ± 1.43 (0.62; -0.02–1.57) 0.146
3 months 1.80 ± 1.68 (1.38; 0.64–2.64) 0.003
6 months 2.49 ± 2.00 (2.05; 1.45–3.26) <0.001
12 months 1.49 ± 0.92 (1.36; 0.89–2.07) 0.001
7.9 ± 2.2 y. 0.84 ± 1.57 (0.94; 0.38–1.55) 0.090
CTLA4 0.00 ± 1.07 (-0.10; -0.76–0.72) 1 week 0.80 ± 1.75 (0.37; -0.54–2.27) 0.950
1 month 0.36 ± 1.27 (-0.01; -0.47–1.04) 0.786
3 months 0.50 ± 1.49 (0.30; -0.41–0.83) 0.840
6 months 1.18 ± 1.47 (0.85; 0.08–2.14) 0.038
12 months 0.47 ± 1.38 (0.27; -0.21–0.70) 1.000
7.9 ± 2.2 y. 0.03 ± 1.12 (0.02; -0.66–0.83) 0.900
FOXP3 0.00 ± 0.73 (0.15; -0.33–0.42) 1 week 0.35 ± 1.45 (0.03; -0.67–0.78) 1.000
1 month −0.20 ± 0.89 (-0.03; -0.63–0.19) 0.730
3 months 0.00 ± 1.20 (-0.04; -0.60–0.45) 0.728
6 months 0.27 ± 1.02 (0.19; -0.40–0.90) 1.000
12 months −0.13 ± 0.81 (-0.22; -0.54–0.05) 1.000
7.9 ± 2.2 y. −0.30 ± 0.92 (-0.39; -0.95–0.30) 0.846
GZMB 0.00 ± 1.94 (0.37; -1.28–1.56) 1 week −0.09 ± 2.16 (-0.34; -1.38–0.83) 0.728
1 month 0.70 ± 1.51 (0.80; -0.31–1.40) 0.505
3 months 1.42 ± 1.79 (1.18; 0.08–2.19) 0.200
6 months 2.15 ± 1.74 (1.98; 1.20–3.03) 0.004
12 months 1.35 ± 1.14 (1.38; 0.75–1.98) 0.046
7.9 ± 2.2 y. 0.46 ± 2.09 (0.99; -0.47–1.94) 0.708
IL10 0.00 ± 1.46 (-0.29; -1.13–0.91) 1 week 3.98 ± 2.56 (4.20; 2.11–5.51) <0.001
1 month 1.29 ± 2.16 (0.76; 0.13–2.44) 0.045
3 months 1.32 ± 1.72 (1.21; -0.02–2.06) 0.035
6 months 2.40 ± 2.05 (2.36; 0.91–3.88) <0.001
12 months 0.61 ± 2.09 (0.22; -1.10–2.17) 0.305
7.9 ± 2.2 y. 0.90 ± 1.67 (0.92; -0.44–1.94) 0.082
IL2RA 0.00 ± 0.66 (-0.04; -0.57–0.62) 1 week 0.43 ± 1.53 (-0.03; -0.58–1.03) 1.000
1 month −0.06 ± 0.86 (-0.08; -0.66–0.34) 1.000
3 months 0.07 ± 1.22 (-0.08; -0.56–0.71) 1.000
6 months 0.26 ± 1.13 (0.19; -0.35–1.03) 1.000
12 months −0.34 ± 0.71 (-0.25; -0.71–0.03) 1.000
7.9 ± 2.2 y. 0.02 ± 0.87 (0.08; -0.78–0.80) 0.993
IL4 0.00 ± 1.00 (-0.28; -0.77–0.78) 1 week 0.27 ± 4.18 (-1.10; -2.47–2.13) 0.514
1 month 0.87 ± 2.01 (0.45; -0.57–2.15) 0.259
3 months 1.29 ± 2.10 (0.90; -0.09–3.01) 0.210
6 months 1.11 ± 2.34 (0.48; -0.57–2.21) 0.372
12 months 1.24 ± 2.33 (0.70; -0.29–1.73) 0.495
7.9 ± 2.2 y. −0.54 ± 1.14 (-0.16; -1.45–0.31) 0.476
NOTCH 0.00 ± 0.67 (-0.06; -0.42–0.55) 1 week 0.14 ± 1.30 (-0.22; -0.45–0.15) 1.000
1 month −0.30 ± 0.72 (-0.48; -0.65 to -0.15) 0.040
3 months 0.23 ± 1.05 (-0.04; -0.35–0.34) 0.963
6 months 0.41 ± 1.04 (0.03; -0.29–0.96) 1.000
12 months −0.01 ± 0.63 (-0.05; -0.37–0.30) 1.000
7.9 ± 2.2 y. 0.20 ± 0.92 (0.05; -0.46–0.74) 0.860
PDCD1 0.00 ± 0.92 (0.24; -0.73–0.67) 1 week 0.14 ± 2.24 (-0.43; -1.26–1.28) 0.950
1 month −0.29 ± 1.33 (-0.54; -1.00 to -0.07) 0.225
3 months 0.65 ± 1.68 (0.18; -0.49–1.54) 1.000
6 months 1.54 ± 1.79 (1.24; 0.40–2.67) 0.009
12 months 0.35 ± 1.39 (0.13; -0.21–1.06) 1.000
7.9 ± 2.2 y. −0.04 ± 1.41 (0.27; -0.78–0.91) 0.787
PRF1 0.00 ± 1.63 (0.43; -0.91–1.28) 1 week −0.17 ± 1.87 (-0.16; -1.38–0.53) 0.746
1 month 0.24 ± 1.11 (0.28; -0.53–0.78) 0.888
3 months 0.97 ± 1.43 (0.81; -0.02–1.50) 0.468
6 months 1.42 ± 1.63 (1.17; 0.44–2.51) 0.066
12 months 0.77 ± 1.52 (1.14; 0.43–1.73) 0.475
7.9 ± 2.2 y. 0.56 ± 1.99 (0.94; -0.02–1.96) 0.438
TGFB 0.00 ± 1.38 (0.24; -0.53–0.98) 1 week 1.47 ± 1.54 (1.31; 1.00–1.62) 0.002
1 month 0.97 ± 0.76 (0.91; 0.58–1.14) 0.031
3 months 1.28 ± 1.11 (1.04; 0.70–1.45) 0.010
6 months 1.36 ± 1.30 (1.27; 0.80–1.84) 0.003
12 months 0.71 ± 1.25 (0.98; 0.53–1.38) 0.054
7.9 ± 2.2 y. 0.46 ± 1.65 (0.76; 0.16–1.25) 0.146
TNFA 0.00 ± 1.17 (0.17; -0.41–0.76) 1 week 0.51 ± 1.54 (0.17; -0.58–1.55) 0.960
1 month 0.51 ± 1.02 (0.48; -0.19–0.98) 0.904
3 months 0.76 ± 1.22 (0.40; -0.05–1.39) 0.755
6 months 0.74 ± 1.26 (0.56; -0.21–1.77) 0.732
12 months 0.26 ± 0.94 (0.04; -0.35–0.73) 0.909
7.9 ± 2.2 y. 0.41 ± 1.25 (0.52; -0.12–1.13) 0.708
TNFRSF18 0.00 ± 1.12 (0.10; -0.53–0.47) 1 week 0.95 ± 1.24 (0.69; 0.15–2.01) 0.051
1 month 0.92 ± 0.86 (0.94; 0.58–1.21) 0.016
3 months 0.92 ± 0.95 (0.89; 0.41–1.35) 0.042
6 months 1.03 ± 1.40 (0.84; 0.02–1.84) 0.052
12 months 0.51 ± 1.79 (1.10; 0.13–1.55) 0.064
7.9 ± 2.2 y. 1.02 ± 3.54 (0.47; -0.16–1.13) 0.124