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. 2019 Jan 15;9:1922. doi: 10.3389/fphys.2018.01922

FIGURE 3.

FIGURE 3

Comparison of the effect of cyclophilin D knock-out on acute pancreatitis caused by L-arginine and L-histidine. Cyclophilin D knock-out (Ppif-/-) or wild type (Wt) mice received either intraperitoneal injections of either 8% L-arginine or 7% L-histidine (both: pH 7.4, 2 × 4 g/kg, at 1 h intervals) and were sacrificed at 72 h after the first L-arginine/L-histidine injection: (A) overall, (B) oedema, (C) inflammation and (D) necrosis histopathological scores; (E) serum amylase, (F) pancreatic trypsin activity, (G) pancreatic myeloperoxidase (MPO) activity and (H) lung MPO activity. ∗p < 0.05 vs. L-histidine with Wt mice. Values are means ± SEM of 6–8 animals per group.