FIGURE 5.

Effect of allosteric modulators of GPRC6A on L-arginine-induced acute pancreatitis. Mice received intraperitoneal injections of either 8% L-arginine (pH 7.4, 2 × 4 g/kg, at 1 h interval) and were sacrificed at 72 h after the first L-arginine injection: (A) Effects of GPRC6A antagonist Cpd1 in vivo, representative images of pancreatic histopathology (H&E, ×200, scale bar 50 μm) and scores – (B) overall, (C) oedema, (D) inflammation, and (E) necrosis. Values are means ± SEM from six mice/group.