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. 2018 Nov 13;68(2):337–348. doi: 10.2337/db18-0903

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© 2018 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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The MafA/MafB regulator has activity similar to that of MafA₂ in adult islet βMafBTg β-cells. A: ChIP analysis reveals that MafB binds to Insulin and G6pc2 control sequences in 2-month-old βMafBTg islet nuclei. Fold enrichment was calculated relative to the albumin promoter (n = 3). B: MafB enhances the expression of Insulin, G6pc2, and Ccnd2 in 2-month-old βMafBTg islets. qPCR signals were normalized to Gapdh (n = 8–10). C: βMafBTg and MafA^fl/fl have the same fasting blood glucose levels and ability to clear a blood glucose bolus in IPGTT assays. D: The number of Ki67⁺-proliferating islet β-cells between βMafBTg and MafA^fl/fl mice were unchanged (n = 3–4). *P < 0.05.