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NLRP3 is activated in the urothelium during diabetes. Inflammasome activity (caspase-1) is increased in urothelia from diabetic mice. Urothelia were isolated and stained with a FAM FLICA Caspase-1 Assay Kit (ImmunoChemistry Technologies) as described. All mice were examined at 15 weeks of age. Bars are mean ± SEM. n = 18 (nondiabetic [non-diab]) and 17 (diabetic [diab]). *P < 0.05 by Student two-tailed t test. Geo Mean, geometric mean.
