Figure 5. Pharmacological inhibition of PRMT5 has strong anti-tumor effects. T24 cells were injected into mice. EPZ015666 were administrated 14 days after injection. A. Morphology of subcutaneous tumors at 4 weeks after transplantation. B. Body weight of mice dosed with oral EPZ or vehicle (Control). C. Tumor volume over time as indicated. D. Tumor weight at 4 weeks after transplantation. E. qRT-PCR analysis of mRNA level of BCLXL and c-IAP1 in excised tumors. *P < 0.05, ** P < 0.01 vs. control.
