Fig. 7.

Effects of methamphetamine alone or in combination with RO5263397 on delay discounting during chronic methamphetamine treatment. ‘Pre-chronic’ (column 1) represent data collected prior to initiation of chronic methamphetamine, no RO5263397 was administered in either group. ‘Cycle 1,’ ‘cycle 2,’ ‘cycle 3,’ and ‘cycle 4’ (columns 2 – 5) represent data collected between days 3 – 10, 13 – 20, 23 – 30, and 33 – 40 of twice-daily methamphetamine treatment, respectively; 5.6 mg/kg RO5263397 was administered to the group labeled ‘5.6 RO’ prior to each test. For the top 2 rows, see Figure 5, left for ordinates and abscissas. For the bottom row, see Figure 5, right for ordinates and abscissas