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. Author manuscript; available in PMC: 2019 Jan 22.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 Mar 16;323:16–25. doi: 10.1016/j.taap.2017.03.015

Fig. 1.

Fig. 1.

Effects of CeO2 (3.5 mg/kg) exposure on pulmonary inflammation and fibrotic cytokine secretion. PMN infiltration in BAL fluid and increased ATII cells isolated from lung tissues of CeO2-exposed rats at different time points after exposure were demonstrated in panel A and B, respectively. AM were harvested from control or CeO2-exposed rats and cultured ex vivo. TGF-β1 (C) was measured in the AM-conditioned supernate using ELISA. The effect of first BALF from control or CeO2-exposed rats on proliferation of fibroblasts from naïve rats were monitored. The BALF was used with no dilution as 100% or at 75%, 50% or 25% concentration of the CeO2-exposed BALF (D). The values are expressed as means ± SE, n = 6. *Significantly different from saline controls, p < 0.05. +Significantly different from the previous dilution, p < 0.05. The dotted line indicates control.