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. Author manuscript; available in PMC: 2019 Jan 22.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 Mar 16;323:16–25. doi: 10.1016/j.taap.2017.03.015

Fig. 2.

Fig. 2.

Cerium oxide exposure induced pulmonary fibrosis. Soluble collagen in the first BALF (A) and hydroxyproline content in lung tissue (B) from control and cerium oxide (3.5 mg/kg)-exposed rats. Illuminated CeO2 particles, using dark field-based illumination, were clearly detected in fibroblasts from particle-exposed lungs (C), but not in controls. Light micrograph of sirius red staining for collagen formation in the control (D) and CeO2-exposed (E) lung tissue at 28 days post-exposure. Arrows indicate increased collagen (scale bar = 20 μm). Immunoblot analysis of α-SMA in control or CeO2-exposed lung tissues (F) at different time points after exposure. TEM micrographs of control (G) and CeO2-exposed (H) lung tissue at 28 days post-exposure (bar = 1 μm). *Significantly different from control at p < 0.05.