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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Nature. 2018 Jul 11;560(7716):128–132. doi: 10.1038/s41586-018-0308-7

Fig. 5. Putative multivalent complex of Shh-N with Ptch1 and its co-receptors.

Fig. 5

a, Complex of Shh-N and Cdo-Fn3 (pdb code: 3D1M) with interaction areas on Shh-N in red. b, Complex of Shh-N and Ihog-Fn3 (pdb code: 2IBG) with interaction areas on Shh-N in red. Hypothetical model of Ptch1*–Shh-N–Cdo complex or Ptch1*–Shh-N-Ihog complex was generated by docking Shh-N-Cdo-Fn3 or Shh-N-Ihog-Fn3 to the Ptch1*– Shh-N structure. c, Model of putative collaboration between Shh-N–Ptch1 and co-receptors or Ptch itself in Hh signaling.