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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Nature. 2018 Jul 11;560(7716):128–132. doi: 10.1038/s41586-018-0308-7

Extended Data Fig. 1. Sequence alignment of human Ptch1 and Ptch2, mouse Ptch1 and Drosophila Ptch.

Extended Data Fig. 1

The residue numbers of hPtch1 are indicated above the protein sequence. The transmembrane helices and secondary structures of ECDs are labeled (structural elements of ECD-II with asterisk). Residues under the dashed lines are excluded from the 3D reconstruction.