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. Author manuscript; available in PMC: 2019 Apr 5.
Published in final edited form as: Science. 2018 Aug 23;362(6410):eaas8843. doi: 10.1126/science.aas8843

Fig. 4. Physiological importance of the Ca2+-mediated interface of SHH-N.

Fig. 4

(A) The interaction details of PTCH1-A and the globular portion of SHH-N. (B) The interaction details of PTCH1-B and SHH-N. (C) The structure of SHH-N with FNIII domain of CDO (PDB code: 3D1M). (D) The structure of IHH-N with FNIII domain of BOC (PDB code: 3N1M). (E) The structure of SHH-N with 5E1 Fab (PDB code: 3MXW). (F) The structure of SHH-N with Hedgehog-interacting protein (HHIP) (PDB code: 3HO5).