Table 1.
List of representative auto antibodies to cerebellar antigens in paraneoplastic cerebellar degenerations.
|
Well Characterized Autoantibodies,
Suggestive of a Specific Disease |
Autoantibodies Found in Different Conditions,
Suggestive of Autoimmune Mechanisms |
||
|---|---|---|---|
| Anti-TG 2, 6 | Gluten ataxia | Anti-VGCC (P/Q type) | PCD (SCLC), PACA |
| Anti-Yo | PCD (breast, uterus and ovarian cancers) | Anti-Homer-3 | Neoplasm*, PIC, PACA |
| Anti-Hu | PCD (SCLC) | Anti-GluRδ2 | PIC, PACA |
| Anti-CV2 | PCD (SCLC, thymoma) | Anti-GAD65 (low titer) | PACA |
| Anti-Ri | PCD, paraneoplastic OMS (breast cancer) |
Less well characterized autoantibodies Reported only in a few patients with cerebellar ataxias |
|
| Anti-Ma2 | PCD (Testis and lung cancers) | ||
| Anti-GAD65 (high titer) | Anti-GAD65 antibody-associated ataxia | PCA-2 | PCD (rare) |
| Partially characterized autoantibodies | Anit-glycine R | Paraneoplastic OMS (rare) | |
| Anti-mGluR1 | Neoplasm* | ||
| Anti-Tr | PCD (Hodgkin’s lymphoma) | Anti-Ca/ARHGAP26 | Neoplasm*, unknown |
| Anti-CARP VIII | Neoplasm* | ||
| Anti-PKCγ | Neoplasm* | ||
| Anti-Nb/AP3B2 | Unknown | ||
| Anti-Sj/ITPR1 | Unknown | ||
| Anti-LGl1 | Unknown | ||
| Anti-CASPR-2 | Unknown | ||
| Anti-neurochondrin | Unknown | ||
*Association was reported only in a few patients with neoplasm. Unknown conditions might be PACA.
Abbreviations: PCD; paraneoplastic cerebellar degeneration, PIC; post-infectious cerebellitis, PACA; Primary autoimmune cerebellar ataxia, SCLC; small cell lung cancer.