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. 2018 Dec 11;17(2):2257–2265. doi: 10.3892/ol.2018.9822

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — miR-744 is upregulated in PCa, and promotes PCa cell growth. (A) miR-744 is overexpressed in PCa tissues and cell lines. Reverse transcription-quantitative polymerase chain reaction was performed to measure the expression level of miR-744. (B) miR-744 inhibitor successfully reduced miR-744 levels in PC3 cells. (C) PC3 cells transfected with miR-744 inhibitor or NC sequence were cultured for 48 h, and cell viability was 1analyzed using the CCK-8 assay. (D) miR-744 knockdown decreased PC3 colony formation capability to (E) a statistically significant degree. (F) miR-744 knockdown increased the apoptotic cell population in PC3 cells (×200 magnification) to (G) a statistically significant degree. *P≤0.05 vs. respective NC (n=3). Prostate cancer, PCa; miR, microRNA; NC, negative control; PCa, prostate cancer.