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. 2018 Dec 11;17(2):2257–2265. doi: 10.3892/ol.2018.9822

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Knockdown of LKB1 reverses the effects of miR-744 silencing in PC3 cells. Co-transfection of LKB1-siRNA successfully restored LKB1 expression in PC3 cells and downregulated miR-744 at the (A) miR and (B) protein level. (C) LKB1-siRNA reversed PC3 cell viability inhibition produced by miR-744 silencing. (D) LKB1-siRNA reversed the reduction in colony formation capability induced by miR-744 downregulation. *P≤0.05 vs. respective NC (n=3). LKB1, liver kinase B1; miR, microRNA; siRNA, small interfering RNA; NC, negative control.