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. 2018 Dec 17;17(2):2040–2046. doi: 10.3892/ol.2018.9837

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — USP22 expression and its association with Survivin, Aurora-B and Ki-67 in OSCC. (A) Expression of USP22, Survivin, Aurora-B and Ki-67 was examined by immunohistochemistry in normal oral mucosa and OSCC tissues. In normal oral mucosa, USP22 were only distributed in the basal and parabasal layers and exhibited weak staining. In well-differentiated OSCC cases, USP22-positive cells were observed predominantly in the periphery of the tumor nests, while in poorly differentiated OSCC cases, USP22-positive cells were present throughout the tumor nests. The expression patterns of Survivin, Aurora-B and Ki-67 appear similar to USP22 in the same cases. (B) The quantity of high or low expression of USP22, Survivin, Aurora-B and Ki-67 in 90 OSCC cases. The quantity of high USP22, Survivin, Aurora-B and Ki-67 expression cases were 46/90, 51/90, 37/90 and 25/90 respectively. The quantity of low USP22, Survivin, Aurora-B and Ki-67 expression cases were 44/90, 46/90, 53/90 and 65/90 respectively. USP22, ubiquitin-specific protease 22; Ki-67, antigen Ki-67; OSCC, oral squamous cell carcinoma.