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. 2019 Jan 21;19:96. doi: 10.1186/s12885-019-5290-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Genomic profiling of the “Pilot-TNBC” cohort. a Tile plot illustrating patients (columns) ordered by primary/metastatic status and by mutation frequency for the top 25 mutated genes; b Stacked bar plot illustrates the frequency of mutations observed in specific cellular signaling pathways: cell cycling, p53, PI3K/mTOR, RAS/MAPK, and RTK/GF signaling pathways [29]. Variants of unknown significance (VUS) were included for these analyses. Wt, wild type; SubIns, substitution and insertion; Sub, substitution; Ins, insertion; Del, deletion, Met, metastatic tumor; Prim, primary tumor