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. 2019 Jan 22;17:9. doi: 10.1186/s12951-019-0448-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — 75 nm AgNP treatment depletes ER calcium stores and leads to ER stress. a Relative mRNA levels of ER stress markers in MCF-7/KCR cells treated with 75 nm AgNPs. b Protein levels of ER stress markers detected by immunoblot. c Densitometric quantitation of GADD153 protein levels. d Histogram of real-time calcium imaging from at least 5 ROIs (Region of interest) and e fluorescent calcium imaging of untreated and 75 nm AgNPs-treated MCF-7/KCR cells upon carbachol administration. Pictures were taken before and 1 min after carbachol exposure. f Representative bar graph of cytoplasmic calcium released on carbachol exposure. The values represent the mean ± standard deviation calculated from three independent experiments (*P < 0.03 ****P < 0.0001, Fisher’s LSD test)