Table 2.
Correlations of protein expression levels with clinicopathological features
Clinico-path parameters | No of cases (%) | HLAB | 14-3-3 β | LTBP-3 | ADAMTS2 | Wnt-5a | MRLC 2/3 | Jagged-2 | nm23 H2 | SRPX | RECK |
---|---|---|---|---|---|---|---|---|---|---|---|
Age | 0.923 | 0.273 | 0.132 | 0.246 | 0.437 | 0.173 | 0.644 | 0.745 | 0.145 | 0.559 | |
< 65 | 35 (29) | ||||||||||
≥ 65 | 84 (71) | ||||||||||
Gender | 0.556 | 0.363 | 0.178 | 0.938 | 0.562 | 0.709 | 0.515 | 0.866 | 0.681 | 0.215 | |
F | 59 (50) | ||||||||||
M | 60 (50) | ||||||||||
Tumor location | 0.230 | 0.318 | 0.231 | 0.444 | 0.317 | 0.078 | 0.589 | 0.736 | 0.534 | 0.036 | |
Colon | 82 (69) | ||||||||||
Rectum | 37 (31) | ||||||||||
Histological type | 0.106 | 0.001* | 0.952 | 0.621 | 0.192 | 0.792 | 0.044* | 0.158 | 0.526 | 0.659 | |
Non mucinous | 102 (86) | ||||||||||
Mucinuo | 16 (14) | ||||||||||
Histological grade | 0.020* | 0.031* | 0.743 | 0.326 | 0.266 | 0.402 | 0.646 | 0.032* | 0.149 | 0.327 | |
High grade | 95 (81) | ||||||||||
Low grade | 23 (191) | ||||||||||
Vascular invasion | 0.556 | 0.200 | 0.500 | 0.730 | 0.279 | 0.584 | 0.038* | 0.048* | 0.401 | 0.166 | |
Negative | 90 (76) | ||||||||||
Positive | 29 (24) | ||||||||||
Perineural invasion | 0.017* | 0.466 | 0.194 | 0.457 | 0.300 | 0.598 | 0.664 | 0.080 | 0.925 | 0.747 | |
Negative | 109 (92) | ||||||||||
Positive | 9 (8) | ||||||||||
TNM stages | 0.394 | 0.226 | 0.647 | 0.664 | 0.508 | 0.403 | 0.374 | 0.147 | 0.184 | 0.257 | |
I | 20 (17) | ||||||||||
II | 42 (36) | ||||||||||
III | 34 (29) | ||||||||||
IV | 21 (18) | ||||||||||
Distant metastasis | 0.307 | 0.850 | 0.003* | 0.013* | 0.503 | 0.833 | 0.808 | 0.418 | 0.681 | 0.210 | |
No | 89 (75) | ||||||||||
Yes | 29 (25) | ||||||||||
Nodal status | 0.227 | 0.417 | 0.403 | 0.336 | 0.894 | 0.101 | 0.283 | 0.413 | 0.463 | 0.194 | |
Negative | 66 (58) | ||||||||||
Positive | 47 (42) | ||||||||||
Depth of invasion | 0.426 | 0.041* | 0.497 | 0.855 | 0.095 | 0.152 | 0.054 | 0.092 | 0.110 | 0.245 | |
T1/T2 | 23 (20) | ||||||||||
T3/T4 | 93 (80) | ||||||||||
5-year recurrence# | 0.104 | 0.120 | 0.075 | 0.041* | 0.671 | 0.781 | 0.763 | 0.761 | 0.673 | 0.654 | |
Recurrence free | 58 (79) | ||||||||||
Recurrence | 15 (21) | ||||||||||
Cause of death | 0.025* | 0.139 | 0.005* | 0.055 | 0.380 | 0.650 | 0.488 | 0.144 | 0.390 | 0.265 | |
CRC | 37 (30) | ||||||||||
Other cause | 87 (70) |
*p < 0.05 is considered significant
# Presence of absence of local or distant metachronous recurrence within 5 year follow-up