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. 2018 Dec 7;17(2):1617–1625. doi: 10.3892/ol.2018.9810

Figure 4.

Figure 4.

SOX2 regulated the migration and invasion of BCC cells by targeting of SRPK1. (A) SOX2 knockdown inhibited SRPK1 expression, while (B) SOX2 overexpression promoted SRPK1 expression in BCC cells. SRPK1 knockdown inhibited the (C) migration and (D) invasion of BCC cells. SRPK1 overexpression canceled the SOX2 knockdown-inhibited (E) migration and (F) invasion of BCC cells. (G) SRPK1 silencing downregulated the EMT process of BCC cells. (H) SRPK1 overexpression canceled the SOX2 knockdown-inhibited EMT process of BCC cells. Magnification, ×400. **P<0.01. SOX2, sex determining region Y-box 2; BCC, basal cell carcinoma; SRPK1, serine-arginine protein kinase 1; siRNA, small interfering RNA; p, plasmid; ns, non-significant.