Figure 5.

Sirt7 knockdown decreased the phosphorylation of ERK, STAT3, and inhibited expression of MMP9 and CDK2 in U87 and U251 glioma cells. (A) Western blot was used to detect the key signal molecules, with β-actin used as an internal control. (B) Quantification of the results in (A) Data are expressed as the mean ± standard deviation of triplicate experiments. **P<0.01 indicates significantly different from the siC group. ERK, extracellular signal-regulated kinase; STAT3, signal transducer and activator of transcription 3; MMP9, matrix metallopeptidase 9; CDK2, cyclin-dependent kinase 2; siRNA, small interfering RNA; si-Sirt7, siRNA targeting Sirt7; siC, control siRNA.