Table I.
The top 10 enriched GO terms of upregulated and downregulated DEG profiles.
| A, Upregulated DEGs | |||
|---|---|---|---|
| GO term | Gene count | P-value | Genes |
| Small molecule metabolic process | 171 | 4.64×10−67 | SAR1B, MARCKS, MGST1, PAPSS2, NMNAT3 … |
| Signal transduction | 147 | 7.44×10−65 | TNFSF14, INPP4B, TNFRSF10C, TNFSF13B, CSF3R … |
| Innate immune response | 110 | 1.95×10−63 | CTSS, FGR, KIR2DS5, CLEC7A, CFP … |
| Blood coagulation | 101 | 3.41×10−62 | TUBA4A, CFL1, ABCC4, ATP2B1, THBS1 … |
| Immune response | 87 | 9.61×10−59 | GZMA, IL18, FCAR, SLC11A1, CEBPB … |
| Inflammatory response | 75 | 1.46×10−51 | SELP, IL18, ANXA1, F2RL1, AOAH … |
| Platelet activation | 57 | 7.95×10−42 | PLA2G4A, COL3A1, TIMP1, MAPK14, ITGB3 … |
| Cell adhesion | 75 | 1.60×10−37 | MPZL3, CX3CR1, FPR2, CD300A, GPNMB … |
| Platelet degranulation | 34 | 3.64×10−32 | PPBP, CFL1, CD36, FN1, TUBA4A … |
| Negative regulation of apoptotic process | 71 | 3.83×10−32 | ITGAV, SFRP1, MPO, CD59, TIMP1 … |
| B, Downregulated DEGs | |||
| GO term | Gene count | P-value | Genes |
| Transcription, DNA-dependent | 121 | 2.32×10−49 | FHIT, TCEA2, KANK2, CHD6, ZNF165 … |
| Regulation of transcription, | 97 | 1.36×10−43 | PHB, ZNF610, PDE8B, BMP2, KLF8 … |
| DNA-dependent | |||
| Negative regulation of transcription from | 47 | 3.65×10−25 | HEY2, CRY1, WT1, LPIN1, BMP2 … |
| RNA polymerase II promoter | |||
| Positive regulation of transcription from | 51 | 2.48×10−22 | CIITA, FOXO1, TP53BP1, DDX5, HEY2 … |
| RNA polymerase II promoter | |||
| Positive regulation of transcription, | 40 | 1.54×10−19 | EBF1, MED17, SOX7, IRF7, SOX4 … |
| DNA-dependent | |||
| Negative regulation of transcription, | 35 | 1.12×10−16 | PTPRK, ZNF423, SMARCA4, FOXO1, IFI16 … |
| DNA-dependent | |||
| Cell adhesion | 31 | 3.18×10−13 | PRKD2, ADA, NID2, PNN, FAT1 … |
| Apoptotic process | 35 | 9.38×10−12 | TIAM1, CASP7, CASP7, BMF, KANK2 … |
| Nervous system development | 23 | 1.54×10−11 | NRN1, ARHGEF7, SEMA6A, NOG, DPYSL2 … |
| Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 7 | 2.61×10−11 | HLA-DMB, HLA-DPA1, HLA-DQB1, HLA-DPB1, HLA-DMA … |
GO, Gene Ontology; DEGs, differentially expressed genes.