Table III.
Top 5 GO and KEGG enrichment analyses results of Profile 26 and Profile 1.
| A, GO term | |||
|---|---|---|---|
| Profile | Gene count | P-value | Genes |
| Profile 26 | |||
| Signal transduction | 52 | 9.64×10−25 | ALCAM, CAP1, C5AR1, TANK, CXCL1 … |
| Small molecule metabolic process | 56 | 2.58×10−22 | NAMPT, PDK3, HAL, GPI, ARSG … |
| Blood coagulation | 34 | 2.73×10−21 | ITPR2, JAK2, ACTN1, VEGFA, P2RY1 … |
| Inflammatory response | 25 | 2.41×10−17 | TLR8, TNFAIP6, CXCR2, IL18, KIT … |
| Innate immune response | 31 | 3.59×10−16 | KIT, CLEC7A, EREG, DEFA4, CAPZA2 … |
| Profile 1 | |||
| Transcription, DNA-dependent | 61 | 1.74×10−28 | KANK2, DIDO1, ZNF251, ZBTB10, PATZ1 … |
| Regulation of transcription, DNA-dependent | 43 | 8.48×10−20 | ZNF555, ZIK1, PATZ1, ZBTB10, ZNF514 … |
| Negative regulation of transcription from | 27 | 1.34×10−17 | SORBS3, ZNF8, YBX3, KDM2B, ID3 … |
| RNA Polymerase II promoter | |||
| Positive regulation of transcription, | 23 | 6.16×10−14 | GLI3, ZNF423, KAT6B, IRF, PHB … |
| DNA-dependent | |||
| Negative regulation of transcription, | 21 | 7.95×10−13 | HIC2, MAGED1, BRD7, KAT6B, RASD1 … |
| DNA-dependent | |||
| B, KEGG pathways | |||
| Profile | Gene count | P-value | Genes |
| Profile 26 | |||
| Metabolic pathways | 48 | 3.33×10−18 | AGL, GALNT3, B3GNT5, ALDH2, SCP2 … |
| Lysosome | 18 | 6.37×10−17 | CTSG, PPT1, CD164, CTSS, IGF2R … |
| TNF signaling pathway | 13 | 3.27×10−11 | PTGS2, CREB5, MAP3K5, CXCL5, MLKL … |
| Phagosome | 14 | 1.72×10−10 | CTSS, FCAR, CLEC7A, MPO, TUBA4A … |
| Cytokine-cytokine receptor interaction | 17 | 4.12×10−10 | IL17RA, CSF2RA, CSF3R, CXCL3, TNFSF13B … |
| Profile 1 | |||
| cGMP-PKG signaling pathway | 10 | 1.88×10−07 | MEF2D, MEF2C, GNA12, ADCY9, PIK3R3 … |
| Rap1 signaling pathway | 10 | 1.65×10−06 | PARD3, PIK3R3, FLT4, MLLT4, MAGI2 … |
| Glutamatergic synapse | 7 | 1.69×10−05 | GNG7, CACNA1A, ADCY9, SHANK3, PPP3CC … |
| Purine metabolism | 8 | 3.25×10−05 | ADCY6, NPR1, ADPRM, NUDT5, PDE8B … |
| Pathways in cancer | 11 | 7.73×10−05 | LAMC1, PIK3R3, GLI3, BCR, ADCY6 … |
DEG, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.