Table II.
Diagnostic value of TCT, h-TERC, c-MYC and HPV for cervical lesions.
| Test | Results | CIN and ICC | Normal | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | Misdiagnosis rate (%) | Omission diagnosis rate (%) | Youden's index |
|---|---|---|---|---|---|---|---|---|---|---|
| TCT | + | 47 | 59 | 87.04 | 62.89 | 44.34 | 93.46 | 37.11 | 12.96 | 0.50 |
| − | 7 | 100 | − | − | − | − | − | − | − | |
| h-TERC | + | 35 | 29 | 64.81a | 81.76a | 54.69 | 87.25 | 18.24a | 35.19a | 0.47 |
| − | 19 | 130 | − | − | − | − | − | − | − | |
| c-MYC | + | 24 | 32 | 44.44a | 79.87a | 42.86 | 80.89a | 20.13a | 55.56a | 0.24 |
| − | 30 | 127 | − | − | − | − | − | − | − | |
| HPV | + | 40 | 72 | 74.07c | 54.72b,c | 35.71b | 86.14 | 45.28b,c | 25.93a,c | 0.29 |
| − | 14 | 87 | − | − | − | − | − | − | − |
a
P<0.05 vs. TCT
b
P<0.05 vs. h-TERC
c
P<0.05 vs. c-MYC. TCT, ThinPrep cytological test; HPV, human papillomavirus; h-TERC, human telomerase RNA component; CIN, cervical intraepithelial neoplasia; ICC, invasive cervical cancer.