Table III.

Parallel and serial tests of combined TCT, h-TERC, c-MYC and HPV testing for diagnosis of cervical lesions.

A, Parallel
Method	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)	Misdiagnosis rate (%)	Omission diagnosis rate (%)	Youden's index
TCT + h-TERC	100.00	49.06	40.00	100.00	50.94	0.00	0.49
TCT + c-MYC	94.44	46.54	37.50	96.10	53.46	5.56	0.41
TCT + HPV	98.15	27.67	31.55	97.78	72.33	1.85	0.26
h-TERC + c-MYC	75.93	62.89	41.00	88.50	37.11	24.07	0.39
h-TERC + HPV	88.89	38.99	33.10	91.18	61.01	11.11	0.28
c-MYC + HPV	85.19	37.11	31.51	88.06	62.89	14.81	0.22
TCT + h-TERC + c-MYC	100.00	33.33	33.75	100.00	66.67	0.00	0.33
TCT + h-TERC + HPV	100.00	14.47	28.42	100.00	85.53	0.00	0.14
TCT + c-MYC + HPV	98.15	14.47	28.04	95.83	85.53	1.85	0.13
h-TERC + c-MYC + HPV	90.74	21.38	28.16	87.18	78.62	9.26	0.12
B, Serial
Method	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)	Misdiagnosis rate (%)	Omission diagnosis rate (%)	Youden's index
TCT + h-TERC	51.85	95.60	80.00	85.39	4.40	48.15	0.47
TCT + c-MYC	37.04	96.23	76.92	81.82	3.77	62.96	0.33
TCT + HPV	62.96	89.94	68.00	87.73	10.06	37.04	0.53
h-TERC + c-MYC	33.33	98.74	90.00	81.35	1.26	66.67	0.32
h-TERC + HPV	50.00	97.48	87.10	85.16	2.52	50.00	0.47
c-MYC + HPV	33.33	97.48	81.82	81.15	2.52	66.67	0.31
TCT + h-TERC + c-MYC	25.93	99.37	93.33	79.80	0.63	74.07	0.25
TCT + h-TERC + HPV	38.89	98.11	87.50	82.54	1.89	61.11	0.37
TCT + c-MYC + HPV	27.78	99.37	93.75	80.20	0.63	72.22	0.27
h-TERC + c-MYC + HPV	24.07	98.74	86.67	79.29	1.26	75.93	0.23

TCT, ThinPrep cytological test; HPV, human papillomavirus; h-TERC, human telomerase RNA component.