Table I.

Associations and comparisons between Nuclear/Cytoplasmic epidermal growth factor receptor expression and clinicopathological factors in 172 rectal cancer patients.

			EGFR-N (n)			EGFR-C (n)
Parameter	Variable	No. of cases	Low Exp.	High Exp.	P-value	Low Exp.	High Exp.	P-value
Gender	Male	108	84	24	0.0768	82	26	0.741
	Female	64	51	13		50	14
Age	<60	65	51	14	0.995	49	16	0.742
	≥60	107	84	23		83	24
Pre-Tx tumor status (Pre-T)	T1-T2	81	70	11	0.017a	69	12	0.013a
	T3-T4	91	65	26		63	28
Pre-Tx nodal status (Pre-N)	N0	125	101	24	0.229	103	22	0.004b
	N1-N2	47	34	13		29	18
Post-Tx tumor status (Post-T)	T1-T2	86	77	9	<0.001c	71	15	0.071
	T3-T4	86	58	28		65	25
Post-Tx nodal status (Post-N)	N0	123	99	24	0.312	99	24	0.066
	N1-N2	49	36	13		33	16
Lymphovascular invasion	Absent	157	123	34	0.881	124	33	0.025a
	Present	15	12	3		8	7
Perineural invasion	Absent	167	131	36	0.933	130	37	0.048a
	Present	5	4	1		2	3
Cytoplasmic EGFR expression	Low Exp.	132	105	27	0.540	n/a	n/a	n/a
	High Exp.	40	30	10		n/a	n/a

^aP<0.05

^bP<0.01

^cP<0.001. EGFR-C, cytoplasmic epidermal growth factor receptor; EGFR-N, nuclear epidermal growth factor receptor; Pre-Tx, pre-treatment; Post-Tx, post-treatment; Exp., expression; n/a, not applicable.