Table 2.
Hazard ratio of each covariate using the Cox proportional hazards model*
| Covariate | HR | SE | p-value |
|---|---|---|---|
| Multi-bio marker score in thea | |||
| 2nd quintile | 1.82 | 0.86 | 0.206 |
| 3rd quintile | 2.24 | 1.03 | 0.078 |
| 4th quintile | 1.79 | 0.80 | 0.194 |
| 5th quintile | 1.63 | 0.81 | 0.327 |
| Age | 0.97 | 0.02 | 0.125 |
| Male | 1.02 | 0.34 | 0.949 |
| Education | 0.99 | 0.04 | 0.850 |
| Married (reference) | |||
| Widowed | 0.81 | 0.39 | 0.664 |
| Divorced | 1.63 | 0.94 | 0.394 |
| Never married | 3.82 | 4.21 | 0.224 |
| Having family history of dementia | 0.76 | 0.39 | 0.591 |
| APOE ε4 carrier | 1.21 | 0.33 | 0.491 |
| Baseline MMSE score | 0.95 | 0.08 | 0.501 |
| Baseline CDR sum of boxes | 1.29 | 0.19 | 0.085 |
| Baseline ADAS 13 | 1.09 | 0.03 | 0.001 |
| Baseline hippocampus volume (mm3) | 0.999566 | 0.00 | 0.005 |
| Baseline ventricles volume (ml) | 1.000003 | 0.00 | 0.628 |
*
n = 148.
a
Quintiles were defined by the equation: (–0.006)× Aβ1–42 + 0.012×P-tau181p. HR, hazard ratio; APOE, apolipoprotein E; MMSE, Mini-Mental State Examination; CDR-SB, Clinical Dementia Rating–sum of boxes subscale; ADAS 13, AD Assessment Scale; SE: standard error.