Table 4.

Relationship between baseline covariates and the risk of developing AD in patients with MCI

	Adjusted
Risk levele		Unadjusted		demographica		COgnitive testb		MRI imagingc		backward selectiond
		HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Low (reference group)
Intermediate		1.93	0.86–4.35	1.93	0.85–4.42	1.63	0.70–3.79	2.08	0.85–5.11	2.02	0.83–4.91
High		3.75	1.93–7.26	3.53	1.75–7.12	2.8	1.38–5.71	2.5	1.18–5.31	2.06	0.97–4.38

^*The included covariates in each adjusted categories are listed in Table 1.

^aCovariates included age, sex, education level, marital status, and APOE ε4 carrier status.

^bCovariates included baseline MMSE, baseline CDR sum of boxes, and baseline ADAS 13.

^cCovariates included baseline hippocampus volume and baseline ventricles volume.

^dCovariates included baselines CDR-SB, baseline ADAS13 and baseline hippocampus volumes. P-value for removal from the model was defined as 0.05.

^eThe lowest quintile is labeled low risk, the second quintile is labeled intermediate risk, and the top three quintiles are labeled high risk. MCI, mild cognitive impairment; HR, hazard ratio; CI, confidence interval; MRI, magnetic resonance imaging.