Table 5.

Prognostic power of the AD indices based on CSF biomarkers by time-dependent ROC analysis

Index	AUC
	Year l	Year 2	Year 3	Year 4	Year 5	Year 6
Aβl-42	0.58	0.60	0.63	0.66	0.68	0.74
P-tau181p	0.63	0.61	0.65	0.68	0.72	0.72
T-tau	0.54	0.61	0.65	0.68	0.68	0.69
P-tau181p/Aβl-42	0.63	0.62	0.65	0.70	0.74	0.76
T-tau/Aβl-42	0.57	0.62	0.66	0.70	0.70	0.73
Hulstaert (P-tau), Aβl-42/(240+1.18 × P-tau181p),a [25]	0.60	0.60	0.64	0.68	0.71	0.75
Hulstaert (T-tau), Aβl-42/(240+1.18 × T-tau),a [25]	0.58	0.61	0.66	0.69	0.70	0.74
AD-CSF-index (P-tau181p),a,b [16]	0.63	0.62	0.66	0.70	0.74	0.77
AD-CSF-index (T-tau),a,b [16]	0.57	0.62	0.66	0.70	0.71	0.74
Current studyc	0.62	0.62	0.65	0.70	0.74	0.77

^aIndices were derived from AD patients versus healthy controls.

^{b$\frac{{\text{Aβ}}_{1-42}-{\text{Aβ}}_{\text{minimum}}}{{\text{Aβ}}_{\text{maximum}}-{\text{Aβ}}_{\text{minimum}}}-\frac{tau-ta{u}_{\text{minimum}}}{ta{u}_{\text{maximum}}-ta{u}_{\text{minimum}}}$}. tau was referred to either P-tau_181p or T-tau in this case.

^c(−0.006)×Aβ_1–42 + 0.012×P-tau_181p. AD, Alzheimer’s disease; CSF, cerebrospinal fluid; ROC, receiver operator characteristic; AUC, area under curve.