Table 4: Power results from simulation study.

Details the power results at an α level of 0.05 under varying levels of LD, number of SNPs in the loci, and presence of a direct effect. TWAS not shown as is equivalent to the LDA MR under are simulation procedure.

LD	Number of SNPS	% Variation E explained by SNPs	Method	No Direct effect		Directional Pleiotropy
		Strength of Mediated Effect		Small Effect	Large Effect	Small Effect	Large Effect
			MR	0.058	0.063	----	----
			LDA MR	0.054	0.058	----	----
		0.01	MR-Egger	0.057	0.062	0.059	0.063
			LDA MR -Egger	0.054	0.059	0.055	0.059
			MR	0.524	0.804	----	----
			LDA MR	0.510	0.797	----	----
	J=50	0.2	MR-Egger	0.514	0.795	0.512	0.795
			LDA MR -Egger	0.499	0.787	0.498	0.788
			MR	0.922	0.997	----	----
			LDA MR	0.921	0.997	----	----
		0.5	MR-Egger	0.915	0.997	0.917	0.997
Small LD			LDA MR -Egger	0.914	0.997	0.915	0.997
			MR	0.054	0.057	----	----
			LDA MR	0.051	0.053	----	----
		0.01	MR-Egger	0.054	0.057	0.056	0.056
			LDA MR -Egger	0.050	0.052	0.052	0.051
			MR	0.339	0.576	----	----
			LDA MR	0.321	0.560	----	----
	J=300	0.2	MR-Egger	0.338	0.573	0.341	0.581
			LDA MR -Egger	0.321	0.557	0.325	0.562
			MR	0.877	0.992	----	----
			LDA MR	0.870	0.992	----	----
		0.5	MR-Egger	0.875	0.992	0.875	0.992
			LDA MR -Egger	0.869	0.991	0.869	0.992
		0.01	LDA MR	0.054	0.059	----	----
			LDA MR -Egger	0.052	0.055	0.053	0.055
	J=50	0.2	LDA MR	0.513	0.798	----	----
			LDA MR -Egger	0.389	0.629	0.389	0.637
		0.5	LDA MR	0.919	0.998	----	----
Large LD			LDA MR -Egger	0.784	0.943	0.788	0.941
		0.01	LDA MR	0.049	0.049	----	----
			LDA MR -Egger	0.050	0.049	0.051	0.051
	J=300	0.2	LDA MR	0.318	0.560	----	----
			LDA MR -Egger	0.294	0.523	0.300	0.524
		0.5	LDA MR	0.869	0.992	----	----
			LDA MR -Egger	0.840	0.985	0.842	0.986