Figure 1.

Experimental design and oral glucose tolerance test.

Notes: (A) Animal experimental design and schematic of DJB. (B) Oral glucose tolerance test. DJB and PGZ reversed the glucose intolerance. *P<0.05.

Abbreviations: DJB, duodenal–jejunal bypass; DJB group, MCD–HF diet for 3 months followed by DJB and MCD–HF diet for subsequent 3 months; HF, high fat; HFD, high fat diet; HF group, MCD–HF diet; MCD, methionine–choline-deficient; NC group, normal chow; PGZ group, MCD–HF diet for 3 months followed by treatment with PGZ with MCD–HF diet for subsequent 3 months; PGZ, pioglitazone.