Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 18;13:345–364. doi: 10.2147/DDDT.S176924

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 van Marion et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

GGA^*-59 enhances HSF1 hyperphosphorylation and subsequent HSPA1A boosting in HL-1 cardiomyocytes.

Notes: (A) GGA^*-59 enhances hyperphosphorylation of HSF1, shown by decreased mobility of HSF1 in the gel. (B) GGA^*-59 enhances the ratio of hyperphosphorylated HSF1/HSF1 (quantified higher band/lower band). (C) Representative Western blot showing HSPA1A expression levels for the conditions as indicated. (D) GGA^*-59 treatment enhances HSPA1A protein expression levels after 6 hours treatment, compared to nontreated heat shocked control cardiomyocytes. ^* is P<0.05 compared to Control, ^# is P<0.05 and ^#### is P<0.0001 compared to nontreated cardiomyocytes at 1 hour and 6 hours, respectively.

Abbreviations: GGA, geranylgeranylacetone; HSF1, heat shock factor 1; HS, heat shock.