Table 1.
Induction of CYPs mRNA in human hepatocytes
| CYP isozymes | Test compound | Concentration (μmol/L) | Maximum fold induction | ||
|---|---|---|---|---|---|
| Donor 1 | Donor 2 | Donor 3 | |||
| CYP1A2 | Evocalcet | 0.2–20 | 4.26 | 1.12 | 29.1 |
| Omeprazole | 2–50 | 99.0 | 88.9 | 1,080 | |
| CYP2B6 | Evocalcet | 0.2–20 | 8.67 | 3.40 | 4.75 |
| Phenobarbital | 20–1000 | 11.6 | 27.1 | 23.7 | |
| CYP2C8 | Evocalcet | 0.2–20 | 9.47 | 6.97 | 3.40 |
| Rifampicin | 0.1–25 | 17.3 | 19.0 | 7.10 | |
| CYP2C9 | Evocalcet | 0.2–20 | 2.84 | 2.31 | 1.60 |
| Rifampicin | 0.1–25 | 5.20 | 4.75 | 3.20 | |
| CYP2C19 | Evocalcet | 0.2–20 | 1.53 | 0.900 | 1.02 |
| Rifampicin | 0.1–25 | 1.60 | 2.43 | 1.03 | |
| CYP3A4 | Evocalcet | 0.2–20 | 4.46 | 3.24 | 13.8 |
| Rifampicin | 0.1–25 | 14.1 | 15.2 | 18.2 | |
CYP, cytochrome P450.