Table 1.
ddQTcF (mixed‐effects model) by treatment and timepoint
| Timepoint (h) | WCK 2349 (N = 47) | Moxifloxacin (N = 47) | ||
|---|---|---|---|---|
| Mean | 90% CI | Mean | 90% CI | |
| 0.5 | 2.7 | 0.2 to 5.2 | 2.7 | 0.2 to 5.3 |
| 1 | 1.2 | −1.3 to 3.7 | 6.3 | 3.8 to 8.9 |
| 1.5 | 0.4 | −2.2 to 2.9 | 8.1 | 5.6 to 10.6 |
| 2 | 3.4 | 0.8 to 5.9 | 9.6 | 7.1 to 12.1 |
| 3 | 2.3 | −0.2 to 4.8 | 9.5 | 7.0 to 12.0 |
| 4 | 3.2 | 0.7 to 5.7 | 9.2 | 6.7 to 11.7 |
| 6 | 3.2 | 0.7 to 5.8 | 7.4 | 4.8 to 9.9 |
| 8 | 2.8 | 0.3 to 5.3 | 7.0 | 4.5 to 9.5 |
| 10 | 3.6 | 1.1 to 6.1 | 5.4 | 2.9 to 8.0 |
| 16 | 6.0 | 3.5 to 8.5 | 5.7 | 3.1 to 8.2 |
| 24 | 5.8 | 3.3 to 8.3 | 4.8 | 2.3 to 7.4 |
| 36 | 5.2 | 2.7 to 7.8 | 1.5 | −1.0 to 4.1 |
Data are given in milliseconds. CI = confidence interval; ddQTcF = placebo‐and baseline‐adjusted QT interval corrected for heart rate by the Fridericia formula.