Skip to main content
. Author manuscript; available in PMC: 2019 Jan 22.
Published in final edited form as: Placenta. 2018 Aug 20;70:7–14. doi: 10.1016/j.placenta.2018.08.004

Figure 2. FLT1 and KDR demonstrate divergent effects on EC metabolic activity and EC proliferation, however, EC apoptosis is not affected by FLT1 or KDR.

Figure 2.

(A) MTT assay showed a decrease in EC metabolic activity, which oftentimes is linked to cell proliferation, after KDR knock-down (p<0.01), with no significant effect of FLT1 knock-down on metabolic activity. (B) In contrast, FLT1 ablation resulted in an increase in EC proliferation (p<0.01). Surprisingly, KDR knock-down did not affect EC proliferation. (C) A representative western blot showed that neither FLT1 or KDR ablation led to presence of cleaved caspase-3, a marker of apoptosis. There was also no effect of FLT1 or KDR knock-down on total caspase-3 expression (D).