Table 2A:
Correlation of clinical and laboratory parameters with antigen expression (p value) in PCM group
| Clinical variable | Reference Range | Mean | Groups (# patients) | CD19 | CD27 | CD28 | CD56 | CD117 | CD138 |
|---|---|---|---|---|---|---|---|---|---|
| Level of serum M-protein | 1 </=3 g/dL(12); >3 g/dL (9) | 0.66 | 0.6 | 0.37 | 1 | 0.67 | 1 | ||
| Beta-2 microglobulin | 1.1–2.4 mg/L | 9.14 | <3.5(8);3.5-<5.5(6); >/=5.5(6) | 0.58 | <0.01 | 0.61 | 0.07 | 0.87 | 0.24 |
| Creatinine | M- 0.6 – 1.2mg/dL F- 0.5 – 1.0 mg/dL |
4.4 | </= 1.2(14); >1.2(7) | 1 | 1 | 1 | 0.57 | 0.4 | 1 |
| Calcium | 8.6–10.2 mg/dL | 9.6 | </= 10.5(18); >10.5(4) | 1 | 1 | 1 | 1 | 1 | 1 |
| Albumin | 3.4 – 4.8 g/dL | 3.5 | <3.5(12);>/=3.5(9) | 1 | 0.05 | 0.67 | 0.6 | 0.66 | 1 |
| Lactate dehydrogenase | M- 135–225 U/L F- 135–214 U/L |
190.4 | </= 225(13); >225(6) | 0.32 | 0.56 | 0.62 | 0.07 | 1 | 1 |
| Amyloid | N/A | Presence (6); absence (16) | 1 | 0.1 | 0.66 | 0.05 | 0.65 | 1 | |
| Cast nephropathy | N/A | Presence(3); absence(19) | 1 | 1 | 1 | 0.47 | 0.57 | 0.47 | |
| Serum free light chain ratio | 0.26–1.65 (N) | 2normal (1); mildly abnormal (11); markedly abnormal (10) | 0.56 | 0.05 | 1 | 0.66 | 0.52 | 0.07 | |
| Hemoglobin | M- 13.2–17.7 g/dL F- 11.9–15.5 g/dL |
11.6 | 3abnormal (14); normal(8) | 0.34 | 0.31 | 1 | 0.6 | 1 | 0.25 |
1
One patient did not have level of serum M protein determined.
2
For patients with a kappa-restricted plasma cell clone, the groups compared are normal (0.26–1.65); mildly abnormal (>1.65 and <100); markedly abnormal (>/=100). For patients with a lambda-restricted plasma cell clone, the groups compared are normal (0.26–1.65); mildly abnormal (>0.01 and < 0.26); markedly abnormal (</= 0.01).
3
Abnormal hemoglobin is defined as <13.2 g/dL for males and <11.9 g/dL for females.