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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Exp Neurol. 2018 Nov 2;312:10–19. doi: 10.1016/j.expneurol.2018.11.001

Figure 2:

Figure 2:

Uninjured adult and aged MPG were grown in organ culture for 3 days with PBS (control) or SHH protein and neurites were quantified (A and B). The number of neurites/mm increased 3.5 fold with SHH treatment in adult rats (249%, p=0.0001). The number of neurites/mm increased 5.7-fold with SHH treatment in aged rats (468%, p=0.013). There was no difference in neurite formation in adult and aged rats treated with PBS (control, p=0.085). SHH treatment was 2.7-fold less in aged rats in comparison to SHH treated adult rats (63%, p=0.001). 800X magnification.