Table 1:
Patient and Tumor Characteristics
| Characteristics | All MYC-R | MYC-R Only |
MYC-R + BCL2-R/ BCL6-R |
P value3 | |||
|---|---|---|---|---|---|---|---|
| Number | Percent | Number | Percent | Number | Percent | ||
| Total Patients | 53 | 100 | 19 | 591 | 24 | 462 | |
| Age Median (Range) | 61 (29–80) | 63 (36–80) | 62 (35–76) | ||||
| Male sex | 40 | 75 | 16 | 84 | 14 | 58 | 0.10 |
| Stage III or IV | 43 | 81 | 14 | 74 | 20 | 83 | 0.48 |
| Elevated LDH | 31 (n=51) | 61 | 11 | 58 | 14 | 58 | 1.00 |
| ECOG PS 2–4 | 11 | 21 | 13 | 68 | 4 | 17 | 0.0013 |
| Extranodal sites ≥ 2 | 12 | 23 | 5 | 26 | 6 | 25 | 1.00 |
| Bone marrow positive | 9 | 17 | 3 | 16 | 5 | 21 | 1.00 |
| CSF positive | 3 (n=44) | 7 | 2 (17) | 12 | 1 (21) | 5 | 0.58 |
| IPI Score | |||||||
| 0–1 | 12 | 23 | 4 | 21 | 6 | 25 | 0.76 |
| 2 | 15 | 28 | 5 | 26 | 7 | 29 | |
| 3 | 17 | 32 | 7 | 37 | 8 | 33 | |
| 4–5 | 9 | 17 | 3 | 16 | 3 | 13 | |
| HIV Positive | 5 | 9 | 3 | 16 | 0 | 0 | 0.08 |
| Histology | |||||||
| HGBL DH | 24 | 45 | 0 | 0 | 24 | 100 | NA |
| HGBL NOS | 10 | 19 | 6 | 32 | 0 | 0 | NA |
| DLBCL | 18 | 34 | 13 | 68 | 0 | 0 | NA |
| Plasmablastic | 1 | 2 | 0 | 0 | 0 | 0 | NA |
| Translocations | |||||||
| MYC | 53 (n=53) | 100 | 19 | 100 | 24 | 100 | NA |
| BCL2 | 22 (n=52) | 42 | 0 | 0 | 22 | 92 | NA |
| BCL6 | 5 (n=32) | 16 | 0 | 0 | 5 | 21 | NA |
Based on 32 cases with BCL2 and BCL6 FISH analysis.
Based on 52 cases with BCL2 and/or BCL6 FISH analysis.
MYC-R only versus MYC-R + BCL2-R and/or BCL6-R (Fisher exact for all except Cochran-Armitage trend test for comparison of IPI).
Abbreviations: LDH-lactate dehydrogenase; ECOG-Eastern Cooperative Oncology Group; IPI-international prognostic index; CSF-cerebral spinal fluid-leptomenigeal disease; HIV-human immunodeficiency virus.
HGBL DH-high grade B-cell lymphoma, double-hit, with MYC and BCL2 and/or BCL6 rearrangements. HGBL NOS-High grade B-cell lymphoma, not otherwise specified, that have feature intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) but do not harbor a genetic double hit. Synonym is B-cell lymphoma, unclassifiable with features intermediate between DLBCL and BL. DLBCL-diffuse large B-cell lymphoma. NA-not applicable.