Table 1.

Selected Sirtuin activators and inhibitors.

Compound name	Sirtuin effect(s), other information	Reference(s)
Sirtuin activators
Piceatannol	Natural STAC. Activates SIRT1, but also effects on SIRT3 and SIRT5 as well as other, unrelated targets.	(Gertz et al., 2012; Howitz et al., 2003)
Resveratrol	Natural STAC. Activates SIRT1, but also effects on SIRT3 and SIRT5 as well as, other, unrelated targets.	(Gertz et al., 2012; Howitz et al., 2003)
SRT1720	Synthetic SIRT1 activator, but has off-target effects.	(Milne et al., 2007) (Dai et al., 2010)
SRT2104	Highly specific synthetic SIRT1 activator	(Hoffmann et al., 2013) (Krueger et al., 2015)
1,4-DHP derivative	SIRT1 activator in vitro and in vivo, activating effect on SIRT2 and SIRT3 in the FdL assay	(Mai et al., 2009; Valente et al., 2016)
UBCS039	Synthetic deacetylation activator for SIRT6; also activates SIRT5 desuccinylase activity	(You et al., 2017)
Sirtuin inhibitors
Cambinol	One of the first, weak Sirtuin inhibitors	(Grozinger et al., 2001)
Ex-527	Potent SIRT1 inhibitor selective over SIRT2 and SIRT3	(Gertz et al., 2013; Napper et al., 2005)
AGK2	Widely used SIRT2 inhibitor	(Outeiro et al., 2007)
3′-(3-fluoro-phenethyloxy)-2-anilinobenzamide	Potent SIRT2 inhibitor with high selectivity over SIRT1	(Suzuki et al., 2012)
SirReal2	Potent SIRT2 inhibitor with high selectivity over SIRT1,3,4,5,6	(Rumpf et al., 2015)
Compound 15e	Potent SIRT2 inhibitor with high selectivity over SIRT1,3	(Sundriyal et al., 2017)
UBCS0137 (Compound 39)	Potent SIRT2 inhibitor selective over SIRT1,3,5	(Moniot et al., 2017)
ELT-11c	Very potent pan SIRT1,2,3 inhibitor	(Disch et al., 2013)
Compound 28e	Highly potent SIRT2 inhibitor selective over SIRT1 and SIRT3	(Yang et al., 2017)
Compound 8	Potent SIRT3 inhibitor with selectivity over SIRT1 and SIRT2	(Mahajan et al., 2014)