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. 2019 Jan 22;17(1):e2006552. doi: 10.1371/journal.pbio.2006552

Fig 2. Summary illustration.

Fig 2

Hypoxic pregnancy in sheep increases fetal oxidative stress, reduces fetal growth, and programs NO-independent endothelial dysfunction, vasoconstrictor hyper-reactivity, and hypertension in the adult offspring. Maternal treatment with vitamin C in hypoxic pregnancy increases transplacental oxygenation and fetal antioxidant capacity. This protects fetal growth and restores NO bioavailability, normalizing peripheral vascular function and arterial blood pressure in the adult offspring.