Table 2. Fetal and adult offspring organ weights.
Values are mean ± SEM for the fetal offspring organ weights at 138 dGA and adult offspring organ weights at PM. Groups are normoxia (fetus, n = 12; adult, n = 9), hypoxia (fetus, n = 6; adult, n = 9), hypoxia with vitamin C (fetus and adult, n = 9), and normoxia with vitamin C (fetus and adult, n = 9). Significant (P < 0.05) differences are *versus normoxia, †hypoxia versus hypoxia with vitamin C, and two-way ANOVA with posthoc Tukey test.
| Normoxia | Hypoxia | Hypoxia with vitamin C | Normoxia with vitamin C | |
|---|---|---|---|---|
| Fetal offspring | ||||
| Brain | ||||
| Absolute (g) | 43.3 ± 0.7 | 38.9 ± 2.3* | 41.5 ± 1.0 | 44.0 ± 1.5 |
| Relative (g/kg) | 12.1 ± 0.6 | 14.9 ± 1.0* | 13.0 ± 0.8 | 13.7 ± 1.1 |
| Hypothalamus | ||||
| Absolute (g) | 3.7 ± 0.2 | 4.08 ± 0.2 | 4.3 ± 0.1 | 4.2 ± 0.2 |
| Relative to brain | 0.086 ± 0.006 | 0.106 ± 0.004* | 0.105 ± 0.004* | 0.096 ± 0.004 |
| Cerebellum | ||||
| Absolute (g) | 4.6 ± 0.2 | 4.0 ± 0.2 | 4.5 ± 0.1 | 4.6 ± 0.2 |
| Relative to brain | 0.106 ± 0.003 | 0.104 ± 0.002 | 0.108 ± 0.003 | 0.105 ± 0.002 |
| Hemispheres | ||||
| Absolute (g) | 33.6 ± 0.9 | 28.5 ± 1.8* | 29.8 ± 1.5 | 32.7 ± 1.5 |
| Relative to brain | 0.780 ± 0.016 | 0.733 ± 0.007 | 0.717 ± 0.030 | 0.756 ± 0.010 |
| Heart | ||||
| Absolute (g) | 33.6 ± 2.5 | 26.3 ± 3.0 | 32.2 ± 1.6 | 33.7 ± 2.2 |
| Relative (g/kg) | 9.2 ± 0.6 | 9.7 ± 0.2 | 10.0 ± 0.5 | 10.3 ± 0.7 |
| Liver | ||||
| Absolute (g) | 78.8 ± 5.2 | 56.6 ± 7.2 | 69.5 ± 5.8 | 67.2 ± 8.4 |
| Relative (g/kg) | 21.4 ± 0.8 | 21.0 ± 1.8 | 21.1 ± 1.2 | 18.8 ± 1.0 |
| Adult offspring | ||||
| Brain | ||||
| Absolute (g) | 79.9 ± 1.8 | 84.6 ± 2.1 | 82.0 ± 2.1 | 79.8 ± 2.5 |
| Relative (g/kg) | 3.2 ± 0.2 | 2.8 ± 0.1 | 3.0 ± 0.2 | 2.8 ± 0.1 |
| Hypothalamus | ||||
| Absolute (g) | 8.6 ± 0.3 | 9.2 ± 0.3 | 9.2 ± 0.3 | 8.6 ± 0.5 |
| Relative to brain | 0.108 ± 0.003 | 0.109 ± 0.002 | 0.112 ± 0.004 | 0.107 ± 0.004 |
| Cerebellum | ||||
| Absolute (g) | 10.4 ± 0.3 | 10.6 ± 0.3 | 10.2 ± 0.4 | 10.1 ± 0.4 |
| Relative to brain | 0.130 ± 0.003 | 0.125 ± 0.002 | 0.124 ± 0.004 | 0.127 ± 0.002 |
| Hemispheres | ||||
| Absolute (g) | 60.9 ± 1.4 | 64.8 ± 1.6 | 62.7 ± 1.7 | 61.1 ± 1.7 |
| Relative to brain | 0.762 ± 0.004 | 0.766 ± 0.003 | 0.764 ± 0.005 | 0.766 ± 0.005 |
| Heart | ||||
| Absolute (g) | 221.9 ± 10.9 | 239.5 ± 10.7 | 239.4 ± 9.1 | 226.4 ± 8.5 |
| Relative (g/kg) | 8.4 ± 0.3 | 8.0 ± 0.4 | 8.6 ± 0.5 | 8.0 ± 0.3 |
| Liver | ||||
| Absolute (g) | 397.4 ± 18.9 | 441.9 ± 29.0 | 407.6 ± 11.5 | 457.8 ± 16.8 |
| Relative (g/kg) | 15.3 ± 1.2 | 14.9 ± 1.2 | 14.7 ± 0.9 | 16.2 ± 0.8 |