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. Author manuscript; available in PMC: 2019 Jan 22.
Published in final edited form as: Angew Chem Int Ed Engl. 2017 Sep 22;56(43):13188–13198. doi: 10.1002/anie.201704084

Table 1:

Fluorescent probes for the selective detection of biothiols (individually or in pairs).

Probe Selectivity Biological system Probe Selectivity Biological system
graphic file with name nihms-1003730-t0013.jpg Cys+Hcy Human plasma graphic file with name nihms-1003730-t0014.jpg Hcy Human plasma
Fluorescein derivative[19] Fluorescein derivative[20]
graphic file with name nihms-1003730-t0015.jpg Hcy Human plasma graphic file with name nihms-1003730-t0016.jpg Cys Human plasma
Fluorescein derivative[21] SNF-probe[22]
graphic file with name nihms-1003730-t0017.jpg Cys+Hcy Human plasma graphic file with name nihms-1003730-t0018.jpg Cys+Hcy HepG2 cells
Benzothiazole derivative[23] Coumarin derivative[24]
graphic file with name nihms-1003730-t0019.jpg GSH Human plasma graphic file with name nihms-1003730-t0020.jpg Cys HepG2 cells
Resorufin derivative[25] Coumarin derivative[26]
graphic file with name nihms-1003730-t0021.jpg Cys+Hcy HepG2 cells graphic file with name nihms-1003730-t0022.jpg GSH HeLa cells
FRET dyad[27] BODIPY derivative[28]
graphic file with name nihms-1003730-t0023.jpg GSH HeLa cells graphic file with name nihms-1003730-t0024.jpg Cys PC-12 cells
BODIPY derivative[29] Fluorescein derivatives[30]
graphic file with name nihms-1003730-t0025.jpg GSH B16 cells graphic file with name nihms-1003730-t0026.jpg GSH MCF-7 cells
Pyronin dye[31] BODIPY dye[32]
graphic file with name nihms-1003730-t0027.jpg GSH HeLa cells graphic file with name nihms-1003730-t0028.jpg GSH HeLa cells
KC-Br[33] Coumarinyl aldehyde[8c]
graphic file with name nihms-1003730-t0029.jpg GSH Hep3B cells graphic file with name nihms-1003730-t0030.jpg GSH Human renal cell carcinoma SiHa cells
Phenyl-selenium[34] Coumarin-enone Dye[35]
graphic file with name nihms-1003730-t0031.jpg Cys+Hcy HepG2 cells graphic file with name nihms-1003730-t0032.jpg Cys HeLa cells
NIR dye[36] 8-alkynyl BODIPY[37]
graphic file with name nihms-1003730-t0033.jpg Cys HeLa cells graphic file with name nihms-1003730-t0034.jpg Cys No study
DPP-AC[38] TPE-Py[39]
graphic file with name nihms-1003730-t0035.jpg Cys+GSH HeLa cells graphic file with name nihms-1003730-t0036.jpg Cys+Hcy No study
AHBO[40] Ruthenium complex[41]
graphic file with name nihms-1003730-t0037.jpg GSH MKN-45 cells and HeLa cells graphic file with name nihms-1003730-t0038.jpg GSH MKN-45 cells and HeLa cells
S-S-BODIPY-S[42] MeO-BODIPY-C[43]
graphic file with name nihms-1003730-t0039.jpg GSH+Hcy L929 cells graphic file with name nihms-1003730-t0040.jpg Cys+Hcy HeLa cells
TP3[44] L2[45]
graphic file with name nihms-1003730-t0041.jpg GSH HepG2 cells graphic file with name nihms-1003730-t0042.jpg Hcy HeLa cells
Rhodamine derivative[46] Pyrene derivative[47]
graphic file with name nihms-1003730-t0043.jpg Cys HeLa cells graphic file with name nihms-1003730-t0044.jpg Cys+GSH HeLa cells
Chloro-hydroxyl merocyanine derivative[48] Chloro-dialkylamino-coumarin conjugated with malonitrile[49]