Table 1.
Pathways Altered in Chlorine-Exposed Mice (FDR-adjusted p value<0.05)
| Pathway | FDR |
|---|---|
| Cell cycle: Chromosome condensation in prometaphase | 3.0E-16 |
| Cell cycle: The metaphase checkpoint | 7.5E-14 |
| Cell cycle: Role of APC in cell cycle regulation | 5.1E-09 |
| Cell cycle: Start of DNA replication in early S phase | 6.6E-07 |
| Cell cycle: Spindle assembly and chromosome separation | 8.7E-07 |
| Cell cycle: Initiation of mitosis | 2.9E-06 |
| Cell cycle: Transition and termination of DNA replication | 4.2E-04 |
| Ligand-independent activation of androgen receptor in prostate cancer | 4.2E-04 |
| Immune response: Antigen presentation by MHC class I - cross-presentation | 1.5E-03 |
| Protein folding and maturation: Bradykinin/kallidin maturation | 1.7E-03 |
| DNA damage: ATM / ATR regulation of G2 / M checkpoint | 1.7E-03 |
| Reproduction: Progesterone-mediated oocyte maturation | 2.2E-03 |
| Cell cycle: Sister chromatid cohesion | 2.7E-03 |
| Immune response: IL-6 signaling pathway via JAK/STAT | 2.7E-03 |
| Androgen receptor activation and downstream signaling in prostate cancer | 4.1E-03 |
| Glucocorticoid-induced elevation of intraocular pressure as glaucoma risk factor | 6.8E-03 |
| Cell cycle: Role of Nek in cell cycle regulation | 6.8E-03 |
| Development: Regulation of lung epithelial progenitor cell differentiation | 1.0E-02 |
| Cell cycle: Cell cycle (generic schema) | 1.1E-02 |
| Immune response: IFN-alpha/beta signaling via PI3K and NF-kB pathways | 1.3E-02 |
| DNA damage: Brca1 as a transcription regulator | 1.8E-02 |
| Transcription: Ligand-dependent activation of the ESR1/SP pathway | 1.8E-02 |
| Apoptosis and survival: Granzyme A signaling | 1.8E-02 |
| Transcription: Androgen receptor nuclear signaling | 2.0E-02 |
| CFTR folding and maturation (normal and CF) | 2.0E-02 |
| Immune response: IL-4-induced regulators of cell growth, survival, differentiation and metabolism | 2.0E-02 |
| Aberrant B-Raf signaling in melanoma progression | 2.1E-02 |
| Cytoskeleton remodeling: TGF, WNT and cytoskeletal remodeling | 2.2E-02 |
| DNA damage: ATM/ATR regulation of G1/S checkpoint | 2.2E-02 |
| Ovarian cancer: Main signaling cascades | 2.3E-02 |
| Transcription: Epigenetic regulation of gene expression | 2.5E-02 |
| Immune responseIL-13 signaling via PI3K-ERK pathway | 3.1E-02 |
| Cell cycle: Nucleocytoplasmic transport of CDK/cyclins | 3.5E-02 |
| Immune response: Substance P-stimulated expression of proinflammatory cytokines via MAPKs | 3.6E-02 |
| Mitogenic action of Estradiol / ESR1 (nuclear) in breast cancer | 3.9E-02 |
| Development: Ligand-independent activation of ESR1 and ESR2 | 4.0E-02 |
| Development: WNT signaling pathway | 4.2E-02 |
| Apoptosis and survival: DNA-damage-induced apoptosis | 4.3E-02 |
| Development: Adiponectin signaling | 4.3E-02 |
| Cell cycle: Role of SCF complex in cell cycle regulation | 4.3E-02 |
| Blood coagulation: Platelet microparticle generation | 4.3E-02 |
| Role of IL-23/ T17 pathogenic axis in psoriasis | 4.3E-02 |
| Immune response: Oncostatin M signaling via JAK-Stat | 4.3E-02 |
| Regulation of GSK3 beta in bipolar disorder | 4.5E-02 |
| Development: Thrombopoietin-regulated cell processes | 4.5E-02 |
| DNA damage: Role of Brca1 and Brca2 in DNA repair | 4.5E-02 |
| Substance P-mediated inflammation and pain in sickle cell disease | 4.5E-02 |
| Neurophysiological process: Circadian rhythm | 4.9E-02 |