Table 3:
Relationship of NREM SWA to AV-45 amyloid PET composite after adjusting for age, sex, race, CDR, ApoE4 status, AHI, PLMI, sleep medications, and time
| Dependent Variable |
Co-variate | Estimate | Standard Error |
F-statistic (df) |
p-value |
|---|---|---|---|---|---|
| 1–4.5 Hz SWA | Mean cortical AV-45 amyloid composite | −4.926 | 2.422 | 4.14 (1,28) | 0.052 |
| Age | −0.680 | 0.270 | 6.36 (1,28) | 0.018 | |
| Sex | −8.590 | 2.948 | 8.49 (1,28) | 0.007 | |
| CDR | −3.489 | 3.463 | 1.02 (1,29) | 0.322 | |
| Race | −10.003 | 5.567 | 3.23 (1,27) | 0.083 | |
| ApoE4 status | +2.946 | 3.327 | 0.78 (1,27) | 0.384 | |
| Sleep medications | +3.124 | 4.963 | 0.40 (1,27) | 0.534 | |
| AHI | +0.123 | 0.183 | 0.45 (1,28) | 0.507 | |
| PLMI | +0.084 | 0.062 | 1.83 (1,28) | 0.187 | |
| Time | −0.003 | 0.142 | 0.00 (1,145) | 0.982 | |
| 1–2 Hz SWA | Mean cortical AV-45 amyloid composite | −12.017 | 5.676 | 4.48 (1,28) | 0.043 |
| Age | −1.563 | 0.632 | 6.12 (1,28) | 0.020 | |
| Sex | −20.401 | 6.914 | 8.71 (1,28) | 0.006 | |
| CDR | −10.138 | 8.139 | 1.55 (1,29) | 0.223 | |
| Race | −23.326 | 13.041 | 3.20 (1,27) | 0.085 | |
| ApoE4 status | +6.427 | 7.786 | 0.68 (1,27) | 0.416 | |
| Sleep medications | −8.086 | 11.625 | 0.48 (1,27) | 0.493 | |
| AHI | +0.299 | 0.431 | 0.48 (1,28) | 0.493 | |
| PLMI | +0.184 | 0.146 | 1.59 (1,28) | 0.218 | |
| Time | +0.003 | 0.355 | 0.00 (1,146) | 0.994 | |
| 2–3 Hz SWA | Mean cortical AV-45 amyloid composite | −3.239 | 1.814 | 3.19 (1,28) | 0.085 |
| Age | −0.514 | 0.202 | 6.48 (1,28) | 0.017 | |
| Sex | −6.066 | 2.205 | 7.57 (1,28) | 0.010 | |
| CDR | −1.472 | 2.568 | 0.33 (1,28) | 0.571 | |
| Race | −6.936 | 4.167 | 2.77 (1,28) | 0.107 | |
| ApoE4 status | +2.196 | 2.498 | 0.77 (1,28) | 0.387 | |
| Sleep medications | +1.613 | 3.716 | 0.19 (1,28) | 0.668 | |
| AHI | 0.073 | 0.137 | 0.29 (1,28) | 0.598 | |
| PLMI | +0.067 | 0.046 | 2.09 (1,28) | 0.159 | |
| Time | −0.014 | 0.095 | 0.02 (1,29) | 0.886 | |
| 3–4 Hz SWA | Mean cortical AV-45 amyloid composite | −1.350 | 0.682 | 3.91 (1,28) | 0.058 |
| Age | −0.183 | 0.076 | 5.80 (1,28) | 0.023 | |
| Sex | −2.229 | 0.830 | 7.21 (1,28) | 0.012 | |
| CDR | −0.339 | 0.963 | 0.12 (1,27) | 0.727 | |
| Race | −2.645 | 1.565 | 2.86 (1,27) | 0.102 | |
| ApoE4 status | +0.682 | 0.939 | 0.53 (1,28) | 0.474 | |
| Sleep medications | +0.425 | 1.396 | 0.09 (1,27) | 0.763 | |
| AHI | +0.024 | 0.051 | 0.21 (1,28) | 0.647 | |
| PLMI | +0.024 | 0.017 | 1.94 (1,28) | 0.175 | |
| Time | −0.003 | 0.038 | 0.01 (1,27) | 0.928 |
Linear mixed models were used to calculate the estimates and p-values for the 38 participants with PET imaging. Time: longitudinal sleep monitoring; SWA: slow wave activity; PET: positron emission tomography; NREM: non-rapid eye movement; CDR: clinical dementia rating; AHI: apnea-hypopnea index; PLMI: periodic limb movement index; ApoE4: Apolipoprotein E4