ROC curve analysis of the T1w/T2w ratio indicating area under the curve (AUC), sensitivity (Sen), and specificity (Spec). A, B, and C are the ROC curves separating all PD (A) and PDE (B) patients from controls, and PDE from PDL (C) in Study 1. D, E, and F are the ROC curves separating all PD (C) and PDE (D) subjects from controls, and PDE from PDL (C) in Study 2.