Table 2:

Number of SNPs contributing to the prediction of each phenotype at the P-value threshold of the best-fitted polygenic risk score model

Phenotype^a	Best fitting P_T	N SNPs at P_T	β	Nagelkerke’s Pseudo R²	P empirical^b	FDR Q-value^c
Tics intermediate	0.0001	162	17.3	0.0013	0.95	0.95
Tics broad	0.0022	2386	111.2	0.0048	0.01	0.04
Tics all	0.0022	8448	98.2	0.0046	0.002	0.01
Chronicity score	0.0724	40120	152.4	0.0016	0.07	0.14
OCD symptom severity	0.003	470	22.7	0.0011	0.11	0.15
ADHD symptom severity	0.00015	262	85.9	0.0009	0.19	0.21
ASD symptom severity	0.0016	1969	169	0.0012	0.09	0.14

SNP, single nucleotide polymorphism; OCD, Obsessive-compulsive disorder; ADHD, Attention-deficit/hyperactivity disorder; ASD, autism spectrum disorder; P_T, P-value threshold; FDR, false discovery rate.

For a definition of the outcome measures see Table 1.

Empirical P-value corrected for the number of P-value threshold tested by permuting the phenotype 11,000 times.

Empirical P-value corrected for the number of phenotypes tested using the Benjamini-Hochberg false discovery rate (36).