Skip to main content
. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Traffic. 2018 Dec 7;20(2):110–120. doi: 10.1111/tra.12624

Table 2.

The interacting proteins of the C-terminus of AT1R

Interacting proteins Interaction sites Function References
β-Arrestin 332–338aa Internalization, signaling 122
ARAP1 319–359aa Recycling 123
ATRAP 339–359aa Internalization 124
Ca2+/CaM 307–320aa Desensitization 125
Caveolin YxFxxxxFxxY ER-Golgi transport 9,10
CD74 Membrane proximal region ER retention, degradation 12
DRiP78 YxFxxxxFxxY ER-Golgi transport 9
eNOS 306–325 aa Signaling 126
GABARAP Membrane proximal region
F(x)6LL		 ER-Golgi transport 25,127
GASP 296–359aa Lysosomal sorting 128
GLP 319–359aa Signaling 129
G protein Membrane proximal region Signaling 118,130
Jak2 YIPP Signaling 114
PLCγ1 YIPP Signaling 131
Rab4 Last 10aa Recycling, phosphorylation 132
Rab5 Last 10aa Internalization 133
Rab7 Last 10aa Lysosome transport 132
Rab11 Last 10aa Recycling 132
Rab43 Helix 8 ER-Golgi transport, sorting 66
SHP-1 and 2 YIPP Signaling 134
Tubulin KK ER-Golgi transport 84

ARAP1, AT1R-associated protein 1; ATRAP, AT1R-associated protein; CaM, calmodulin; eNOS, endothelial nitric oxide synthase; GABARAP, γ-aminobutyric acid receptor-associated protein; GASP, GPCR-associated sorting protein; GLP, GDP/GTP exchange-like protein; PLC, phospholipase C; SHP, Src homology domain 2-containing protein tyrosine phosphatase.