Table 3.
Final multiple linear regression model for the association of intratumoral immune cytolytic activity (CYT) with factors present in the glioblastoma (GBM) immune microenvironment
| Variable | Standardized beta coefficient |
Standard error |
t value | p value |
|---|---|---|---|---|
| Immune checkpoints | ||||
| CTLA-4 | 0.15 | 0.02 | 2.2 | 0.028 |
| Immune co-stimulatory receptors | ||||
| CD40 (TNFRSF5) | 0.16 | 0.03 | 2.3 | 0.023 |
| CD137 (TNFRSF9) | 0.15 | 0.02 | 2.1 | 0.042 |
| GITR (TNFRSF18) | 0.15 | 0.02 | 2.4 | 0.020 |
| OX40 (TNFRSF9) | 0.27 | 0.03 | 4.3 | <0.001 |
| Other immunomodulatory factors | ||||
| CSF-1 | 0.21 | 0.03 | 3.1 | 0.003 |
| IL-6 | 0.20 | 0.02 | 2.4 | 0.020 |
| VEGF-A | −0.32 | 0.02 | −4.6 | <0.001 |