Skip to main content
. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Invest Dermatol. 2018 Aug 18;139(2):360–368. doi: 10.1016/j.jid.2018.07.030

Figure 1. Genetic proof of concept study demonstrated that reduced TNAP activity in the Alpl+/− mice inhibited ectopic connective tissue mineralization in the Abcc6−/− mice.

Figure 1.

(a) Muzzle skin biopsies were processed for histopathology followed by von Kossa stains. The Abcc6−/−Alpl+/− mice (lower panel) developed less ectopic mineralization of the dermal sheath of vibrissae in the muzzle skin compared to Abcc6−/−Alpl+/+ mice (upper panel); (b) The amount of calcium in the muzzle skin of Abcc6−/−Alpl+/− mice was significantly decreased as compared to Abcc6−/−Alpl+/+ mice; (c) Plasma PPi levels in the Abcc6−/−Alpl+/+ mice were 30% of that in wild type mice; however, plasma PPi levels in the Abcc6−/−Alpl+/− mice were not statistically different from that in the Abcc6−/− Alpl+/− mice; (d) Plasma levels of PLP were significantly increased in the Abcc6−/−Alpl+/− mice. Values were expressed as mean ± SD; n = 12 - 15 mice per group. **p < 0.01, compared with Abcc6−/−Alpl+/+ mice. Scale bar, 0.4 mm.